^
Association details:
| Biomarker: | UHRF1 rs2261988C>A |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug Class: | EGFR inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Nuclear Pore Glycoprotein 62 Genetic Variant rs9523 is Associated with Clinical Outcomes of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Adenocarcinoma Patients
Published date:
10/01/2021
Excerpt:
We investigated whether genetic variants in miRNA binding sites are associated with the clinical outcome of EGFR-TKIs in lung adenocarcinoma patients….Another three SNPs - DVL2 rs2074216G>A, ARF1 rs11541557G>T, and UHRF1 rs2261988C>A - were significantly associated with worse OS (aHR = 2.19, 95% CI = 1.32–3.66, P = 0.003; aHR = 1.92, 95% CI = 1.24–2.97, P = 0.004; and aHR = 3.8, 95% CI = 1.11–13.04, P = 0.034, respectively) and worse PFS (aHR = 1.72, 95% CI = 1.07–2.76, P = 0.025; aHR = 2.5, 95% CI = 1.65–3.78, P < 0.0001; and aHR = 6.38, 95% CI = 1.85–22.06, P = 0.003, respectively)...
DOI:
https://doi.org/10.2147/PGPM.S329055